Endothelial Growth Factors

These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.

Also Known As:

ECDGF; Endo-GF; Endothelial Growth Factor; Endothelial Growth Factor Polypeptides; Endothelial Cell Derived Growth Factors; Growth Factor, Endothelial; Growth Factor, alpha-Endothelial; Growth Factor, beta-Endothelial; Growth Factors, Endothelial; alpha Endothelial Growth Factor; beta Endothelial Growth Factor; Endothelial Cell-Derived Growth Factors; alpha-Endothelial Growth Factor; beta-Endothelial Growth Factor

Pharmalogical Action Categories:

Growth Substances

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Endothelial Growth Factors: 760
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Endothelial Growth Factors: 760
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Endothelial Growth Factors: 760

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Disease

Drug/Important Bio-Agent (IBA)